Functional magnetic resonance imaging (MRI) versus lung function outcomes in the 40 patients with cystic fibrosis

LCI lung turnover0.76<0.0001#0.85<0.0001#
Scond L10.550.0003#0.62<0.0001#
Sacin L−10.490.0013#0.440.0049
FEV1 z-score−0.64<0.0001#−0.67<0.0001#
FVC z-score−0.57<0.0001#−0.62<0.0001#
RV/TLC %0.540.0003#0.590.0001#

Data are presented as Spearman correlation coefficients; for all correlations we performed a Bonferroni correction: 0.05/12, as appropriate. RFV: impairment of ventilation; RQ: impairment of perfusion; LCI: lung clearance index; Scond and Sacin: normalised phase III slope indices (see main text and supplementary material for explanation); FEV1: forced expiratory volume in 1 s; FVC: functional vital capacity; RV: residual volume; TLC: total lung capacity. Correlation between RFV and RQ from functional MRI (matrix pencil decomposition MRI) and different lung function outcomes: LCI, Scond, Sacin, FEV1, FVC and RV/TLC ratio. #: p-values <0.0042 were considered statistically significant.