Functional magnetic resonance imaging (MRI) versus lung function outcomes in the 40 patients with cystic fibrosis
| RFV | RQ | |||
| r | p-value | r | p-value | |
| LCI lung turnover | 0.76 | <0.0001# | 0.85 | <0.0001# |
| Scond L−1 | 0.55 | 0.0003# | 0.62 | <0.0001# |
| Sacin L−1 | 0.49 | 0.0013# | 0.44 | 0.0049 |
| FEV1 z-score | −0.64 | <0.0001# | −0.67 | <0.0001# |
| FVC z-score | −0.57 | <0.0001# | −0.62 | <0.0001# |
| RV/TLC % | 0.54 | 0.0003# | 0.59 | 0.0001# |
Data are presented as Spearman correlation coefficients; for all correlations we performed a Bonferroni correction: 0.05/12, as appropriate. RFV: impairment of ventilation; RQ: impairment of perfusion; LCI: lung clearance index; Scond and Sacin: normalised phase III slope indices (see main text and supplementary material for explanation); FEV1: forced expiratory volume in 1 s; FVC: functional vital capacity; RV: residual volume; TLC: total lung capacity. Correlation between RFV and RQ from functional MRI (matrix pencil decomposition MRI) and different lung function outcomes: LCI, Scond, Sacin, FEV1, FVC and RV/TLC ratio. #: p-values <0.0042 were considered statistically significant.