TABLE 2

Correlation between lung function parameters with magnetic resonance imaging (MRI)-defined morphological pathologies in lung structure in the 40 patients with cystic fibrosis

	Total score		Subscores
	r	p-value	Wall thickening/bronchiectasis		Mucus plugging		Consolidation		Abscess/sacculation		Special findings
	r	p-value	r	p-value	r	p-value	r	p-value	r	p-value	r	p-value
LCI lung turnover	0.81	<0.0001^#	0.81	<0.0001^#	0.79	<0.0001^#	0.66	<0.0001^#	0.48	0.0015	0.40	0.0109
S_cond L⁻¹	0.70	<0.0001^#	0.68	<0.0001^#	0.65	<0.0001^#	0.60	<0.0001^#	0.28	0.0816	0.41	0.0082
S_acin L⁻¹	0.42	0.0068	0.41	0.0095	0.42	0.0072	0.29	0.0722	0.33	0.0349	0.29	0.0739
FEV₁ z-score	−0.66	<0.0001^#	−0.68	<0.0001^#	−0.62	<0.0001^#	−0.56	<0.0001^#	−0.39	0.0123	−0.23	0.1452
FVC z-score	−0.56	0.0002^#	−0.59	0.0001^#	−0.49	0.0014	−0.51	0.0009^#	−0.36	0.0213	−0.15	0.3670
RV/TLC %	0.60	<0.0001^#	0.62	<0.0001^#	0.55	0.0002^#	0.50	0.0012^#	0.49	0.0012^#	0.15	0.3577

Data are presented as Spearman correlation coefficients; for all correlations we performed a Bonferroni correction: 0.05/36, as appropriate. LCI: lung clearance index; S_cond and S_acin: normalised phase III slope indices (see main text and supplementary material for explanation); FEV₁: forced expiratory volume in 1 s; FVC: functional vital capacity; RV: residual volume; TLC: total lung capacity. Correlation between dedicated morphology MRI score (mean from both readers) and different lung function outcomes: LCI, S_cond, S_acin, FEV₁, FVC and RV/TLC ratio. Calculation of the correlation between each reader and lung function values determined similar values (data not shown). ^#: p-values <0.0014 were considered statistically significant.