Baseline EOS (cells/mm3) | n | Exacerbation rate | % change | P value | ||
ROF | PBO | Rate ratio (ROF vs PBO)(95% CI) | ||||
Moderate or severe exacerbations< 150> 150 | 20802146 | 1.041.00 | 1.081.24 | 0.96 (0.83, 1.11)0.81 (0.71, 0.93) | -3.8%-19.1% | 0.60450.0020 |
Severe exacerbations< 150> 150 | 20802146 | 0.250.24 | 0.280.31 | 0.90 (0.70, 1.15)0.78 (0.61, 0.98) | -10.4%-22.4% | 0.37990.0343 |