TABLE 2

Baseline characteristics of blood eosinophil longitudinal patterns in patients with chronic obstructive pulmonary disease (COPD) (CHAIN cohort) using ≥300 cells·μL–1 as the cut-off point

Persistently high ≥300 cells·μL–1Intermittently variablePersistently low <300 cells·μL–1p-value
Patients n67186171
Male60 (90)156 (84)139 (81)0.298
Age years66±868±967±90.148
Pack-years55±2955±2857±310.779
Active smoking3129270.729
BMI kg·m−229.8±5.528.2±4.928.2±4.70.114
FEV1 L1.80±0.631.63±0.641.69±0.620.150
FEV1 % pred61±1860±2060±190.949
PaO2 mmHg69.6±7.467.5±9.068.9±9.30.446
FVC L3.37±0.943.08±0.923.15±0.930.094
FVC % pred87±2286±2486±220.974
FEV1/FVC54±1153±1154±100.704
6MWD m461±95438±99451±890.175
Dyspnoea mMRC1 (0–3)1 (0–4)1 (0–3)0.212
BODE index1 (0–5)2 (0–6)1 (0–5)0.346
IC/TLC0.36±0.090.34±0.090.35±0.090.091
KCO % pred82±2573±2374±240.059
Charlson index1 (0–5)1 (0–4)1 (0–4)0.158
Inhaled anticholinergic6476710.172
Inhaled β2-agonist7375700.483
Inhaled corticosteroid6468590.233
CAT11 (1–27)12 (2–27)10 (2–24)0.297
IgE total U·L−150 (8–1158)62 (7–690)26 (5–504)<0.001

Data presented as n (%), mean±sd, % or median (5th–95th percentile), unless otherwise stated. BMI: body mass index; FEV1: forced expiratory volume in 1 s; PaO2: arterial oxygen tension; FVC: forced vital capacity; 6MWD: 6-min walk distance; mMRC: modified Medical Research Council; IC/TLC: inspiratory capacity/total lung capacity; KCO: transfer coefficient of the lung for carbon monoxide; CAT: COPD Assessment Test.