Baseline characteristics of blood eosinophil longitudinal patterns in patients with chronic obstructive pulmonary disease (COPD) (CHAIN cohort) using ≥300 cells·μL–1 as the cut-off point
Persistently high ≥300 cells·μL–1 | Intermittently variable | Persistently low <300 cells·μL–1 | p-value | |
Patients n | 67 | 186 | 171 | |
Male | 60 (90) | 156 (84) | 139 (81) | 0.298 |
Age years | 66±8 | 68±9 | 67±9 | 0.148 |
Pack-years | 55±29 | 55±28 | 57±31 | 0.779 |
Active smoking | 31 | 29 | 27 | 0.729 |
BMI kg·m−2 | 29.8±5.5 | 28.2±4.9 | 28.2±4.7 | 0.114 |
FEV1 L | 1.80±0.63 | 1.63±0.64 | 1.69±0.62 | 0.150 |
FEV1 % pred | 61±18 | 60±20 | 60±19 | 0.949 |
PaO2 mmHg | 69.6±7.4 | 67.5±9.0 | 68.9±9.3 | 0.446 |
FVC L | 3.37±0.94 | 3.08±0.92 | 3.15±0.93 | 0.094 |
FVC % pred | 87±22 | 86±24 | 86±22 | 0.974 |
FEV1/FVC | 54±11 | 53±11 | 54±10 | 0.704 |
6MWD m | 461±95 | 438±99 | 451±89 | 0.175 |
Dyspnoea mMRC | 1 (0–3) | 1 (0–4) | 1 (0–3) | 0.212 |
BODE index | 1 (0–5) | 2 (0–6) | 1 (0–5) | 0.346 |
IC/TLC | 0.36±0.09 | 0.34±0.09 | 0.35±0.09 | 0.091 |
KCO % pred | 82±25 | 73±23 | 74±24 | 0.059 |
Charlson index | 1 (0–5) | 1 (0–4) | 1 (0–4) | 0.158 |
Inhaled anticholinergic | 64 | 76 | 71 | 0.172 |
Inhaled β2-agonist | 73 | 75 | 70 | 0.483 |
Inhaled corticosteroid | 64 | 68 | 59 | 0.233 |
CAT | 11 (1–27) | 12 (2–27) | 10 (2–24) | 0.297 |
IgE total U·L−1 | 50 (8–1158) | 62 (7–690) | 26 (5–504) | <0.001 |
Data presented as n (%), mean±sd, % or median (5th–95th percentile), unless otherwise stated. BMI: body mass index; FEV1: forced expiratory volume in 1 s; PaO2: arterial oxygen tension; FVC: forced vital capacity; 6MWD: 6-min walk distance; mMRC: modified Medical Research Council; IC/TLC: inspiratory capacity/total lung capacity; KCO: transfer coefficient of the lung for carbon monoxide; CAT: COPD Assessment Test.