Comparison of lung function and nutritional outcomes in infants with cystic fibrosis and healthy controls at ∼2 years

Cystic fibrosisHealthy controlsDifference (95% CI)p-value
Subjects n6234
Age at test, weeks95.0±7.396.2±7.7−1.24 (−4.39–1.92)0.44
zHeight0.48±1.000.71±1.18−0.23 (−0.69–0.22)0.31
zWeight0.24±0.920.40±0.86−0.16 (−0.54–0.22)0.41
zBMI−0.07±0.92−0.03±0.90−0.04 (−0.42–0.35)0.85
zLCI0.78±0.93−0.03±0.640.81 (0.45–1.17)0.001
zFRCpleth0.85±1.300.16±1.280.69 (0.11–1.26)0.02
zFEV0.5−0.35±1.00−0.14±1.23−0.21 (−0.71–0.29)0.41
zFVC−0.19±0.940.04±0.92−0.23 (−0.66–0.21)0.30
zFEF25-75%−0.41±0.95−0.24±1.15−0.17 (−0.64–0.3)0.48

Data are presented as mean±sd, unless otherwise stated. For numbers of subjects with each outcome at each test occasion see online supplementary table E2. Although not primary outcomes, forced vital capacity (FVC) and forced expiratory flow at 25–75% of FVC (FEF25-75%) results are included in this table to allow comparison with the published literature. z: z-score; BMI: body mass index; LCI: lung clearance index; FRCpleth: plethysmographic functional residual capacity; FEV0.5: forced expiratory volume in 0.5 s.