TABLE 1

Demographic and clinical characteristics of patients who completed treatment with delamanid in Latvia (July 2014 to August 2016) (n=19)

PatientAge yearsSexResistance classificationDrug resistancePrevious treatment historyDelamanid treatment duration in months (weeks)Total MDR-TB treatment duration in monthsCompanion drugsFinal treatment outcome at the end of MDR-TB treatment
130MPre-XDRH, R, E, Z, Am, Km, Cm, PASZ, Cm, Mfx, Pto, Trd, PAS9 (36)14Z, Cm, Mfx, Pto, TrdCured
263MMDRH, R, EZ, Cm, Lfx, Pto, Trd, PAS6 (24)16Z, Lfx, Pto, TrdCured
356MXDRH, R, E, Am, Km, Cm, Ofx, Lfx, Trd, low-dose MfxH, R, E, Z11 (44)0Mfx, Lzd, Pto, Amx/ClvCured
462MPre-XDRH, R, E, Z, Am, Km, Cm, Pto, TrdNo prior treatment10 (40)13Z, Mfx, Lzd, PASCured
566MPre-XDRH, R, E, Z, Cm, Pto, PASNo prior treatment9 (36)12Z, Am, Lfx, Lzd, TrdCured
644MPre-XDRH, R, E, Z, Am, Km, Cm, PtoZ, Mfx, Pto, Trd, PAS10 (40)16Lfx, Lzd, Trd, Amx/ClvLost to follow-up
725MXDRH, R, E, Z, Am, Cm, Mfx, PtoTrd, PAS, Lzd, Bdq, Amx/Clv3 (12)18Trd, PAS, Amx/ClvCured
856MXDRH, R, E, Z, Km, Ofx, Lfx, PAS, low-dose MfxH, R, E, Z9 (36)0Z, Cm, Mfx, Pto, TrdCured
922MXDRH, R, E, Z, Cm, Ofx, Lfx, Mfx, PASE, Z, Cm, Lfx, Pto, Trd6 (24)7Z, Am, Mfx, Lzd, Pto, TrdLost to follow-up
1025MXDRH, R, Z, Km#, Cm#, Ofx, Lfx, Mfx, PASH, R, E, Z9 (36)14Z, Am, Lzd, Pto, TrdCured
1148MXDRH, R, E, Z, Am, Km, Cm, Ofx, Lfx, low-dose Mfx, Pto, Trd, PASNo prior treatment13 (52)13Mfx, Lzd, PAS, Imp/Cls, Amx/ClvCured
1213FPre-XDRH, R, E, Am, Km, Cm, PtoNo prior treatment6 (24)11Z, Cm, Mfx, Trd, Amx/ClvCured
1356MPre-XDRH, R, E, Z, Ofx, Lfx, low-dose Mfx, Pto, PASNo prior treatment14 (58)0Mfx, Lzd, Trd, Amx/ClvCured
1411FXDRH, R, E, Z, Am, Km, Ofx, Lfx, low-dose Mfx, PtoNo prior treatment6 (24)0Z, Cm, Mfx, Lzd, TrdCured
1535MXDRH, R, E, Z, Cm, Ofx, Lfx, Mfx, Pto, PASZ, Am, Pto, Trd, Lzd, Amx/Clv11 (44)19Z, Am, Lzd, Trd, Amx/ClvCured
1653MMDRH, R, E, Z,E, Z, Lfx, Pto, Trd, PAS2 (7)12Z, Lfx, Lzd, Pto, TrdLost to follow-up
1727FPre-XDRH, R, E, Z, Ofx, Lfx, Mfx, PtoAm, Mfx, Trd, Lzd, Amx/Clv6 (24)18Am, Lzd, Trd, Amx/ClvCured
1861MPre-XDRH, R, E, Z, Am, Km, Cm, PASMfx, Pto, Trd, Amx/Clv6 (24)19Lfx, Lzd, Pto, TrdCured
1936FXDRH, R, E, Z, Am, Km, Cm, Ofx, Lfx, Mfx, Pto, Trd, PASTrd, Lzd, Bdq, Amx/Clv, Imp/Cls3 (12)16Lzd, Imp/Cls, Amx/ClvCured

Cured: treatment completed as recommended by the national policy without evidence of failure, and three or more consecutive cultures taken at least 30 days apart are negative after the intensive phase. TB: tuberculosis; MDR: multidrug-resistant; XDR: extensively drug-resistant; H: isoniazid; R: rifampicin; E: ethambutol; Z: pyrazinamide; Am: amikacin; Km: kanamycin; Cm: capreomycin; PAS: para-aminosalicylic acid; Mfx: moxifloxacin; Pto: protionamide; Trd: terizidone; Lfx: levofloxacin; Ofx: ofloxacin; Lzd: linezolid; Amx: amoxicillin; Clv: clavulanate; Bdq: bedaquiline; Imp: imipenem; Cls: cilastatin. #: inconsistent susceptibility test results.