TABLE 3

Association between wheeze phenotypes and symptom severity in the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Leicester Respiratory Cohort (LRC) at ages 2, 4 and 6 years

Indicators of symptom severity#ALSPACLRC
EVWMTWMTW versus EVWEVWMTWMTW versus EVW
Wheeze at 2 years of age n752928229295
 Frequent attacks39.763.62.7 (2.2–3.2)11.545.96.5 (4.1–10.4)
 Shortness of breath43.358.21.8 (1.5–2.2)39.976.24.8 (3.3–7.0)
 Sleep disturbanceNANANA40.474.04.2 (2.9–6.1)
 Interference with activitiesNANANA38.073.64.5 (3.1–6.6)
Wheeze at 4 years of age n519904158340
 Frequent attacks45.374.03.4 (2.7–4.3)7.640.08.1 (4.3–15.1)
 Shortness of breath50.264.11.8 (1.4–2.2)NANANA
 Sleep disturbanceNANANA41.771.33.5 (2.3–5.2)
 Interference with activitiesNANANA37.274.85.0 (3.3–7.5)
Wheeze at 6 years of age n23654379246
 Frequent attacks39.664.72.8 (2.0–3.8)5.141.112.9 (4.6–36.4)
 Shortness of breath53.061.31.4 (1.0–1.9)NANANA
 Sleep disturbance52.462.41.5 (1.1–2.1)43.067.42.7 (1.6–4.6)
 Interference with activitiesNANANA29.178.79.0 (5.1–16.0)
 Speech limitation8.113.41.8 (1.0–3.0)NANANA

Data are presented as % or OR (95% CI), unless otherwise stated. EVW: episodic viral wheeze; MTW: multitrigger wheeze; NA: not available. #: definitions of severity indicators are provided in supplementary table S1; : OR from logistic regression excluding children without wheeze or with non-classifiable wheeze.