TABLE 2

Exposure to occupational lung carcinogens and biomarker mutation frequency

PAHAsbestosSilicaDEFChromePaint
UnexposedExposedp-valueUnexposedExposedp-valueUnexposedExposedp-valueUnexposedExposedp-valueUnexposedExposedp-valueUnexposedExposedp-value
EGFRWT157 (57)13 (57)0.942154 (56)16 (80)0.033161 (57)9 (69)0.371167 (57)3 (50)0.703#167 (57)3 (60)1.0#167 (57)3 (60)1.0#
Mt117 (43)10 (43)123 (44)4 (20)123 (43)4 (31)124 (43)3 (50)125 (43)2 (40)125 (43)2 (40)
HER2+WT155 (96)10 (91)0.4151 56 (96)9 (82)0.084#160 (96)5 (83)0.251162 (95)3 (100)1.0#163 (96)2 (67)0.133#164 (95)1 (100)1.0#
Mt7 (4)1 (9)6 (4)2 (18)7 (4)1 (17)8 (5)0 (0)7 (4)1 (33)8 (5)0 (0)
KRAS§WT219 (92)18 (100)0.624#221 (93)16 (94)1.0#226 (93)11 (92)0.593#233 (93)4 (100)1.0#232 (93)5 (100)1.0#234 (93)3 (75)0.255#
Mt18 (8)0 (0)17 (7)1 (6)17 (7)1 (8)18 (7)0 (0)18 (7)0 (0)17 (7)1 (25)
BRAFƒWT170 (95)15 (94)0.584#172 (96)13 (87)0.174#175 (95)10 (91)0.448#182 (95)3 (75)0.191#181 (95)4 (100)1.0#183 (95)2 (100)1.0#
Mt9 (5)1 (6)8 (4)2 (13)9 (5)1 (9)9 (5)1 (25)10 (5)0 (0)10 (5)0 (0)
ALK##WT142 (88)9 (90)1.0#142 (88)9 (100)0.601#143 (88)8 (100)0.598#148 (88)3 (100)1.0#149 (88)2 (100)1.0#150 (88)1 (100)1.0#
Al19 (12)1 (10)20 (12)0 (0)20 (12)0 (0)20 (12)0 (0)20 (12)0 (0)20 (12)0 (0)
PI3K¶¶WT146 (98)13 (93)0.304#149 (98)10 (91)0.246#154 (98)5 (83)0.141#155 (97)4 (100)1.0#157 (98)2 (67)0.072#157 (98)2 (67)0.072#
Mt3 (2)1 (7)3 (2)1 (9)3 (2)1 (17)4 (3)0 (0)3 (2%)1 (33)3 (2%)1 (33)

Data are presented as n (%), unless otherwise stated. PAH: polycyclic aromatic hydrocarbons; DEF: diesel exhaust fumes; WT: wild type; Mt: mutation; Al: alteration. #: two-sided Fisher tests, others are two-sided Chi-squared tests; : n=297; +: n=173; §: n=255; ƒ: n=195; ##: n=171; ¶¶: n=163.