TABLE 3

Distribution of EGFR mutation type (substitution in exon 21/deletion in exon 19/other or NOS) in relation to occupational exposure

AgentExposureEGFR mutation typeTotal
Substitution in Exon 21#Deletion in Exon 19p-value
exon 21 versus 19 (Fisher)
Other/NOS
AsbestosUnexposed35 (29.7)72 (61.0)0.611 (9.3)118 (100)
Exposed2 (50.0)2 (50.0)0 (0.0)4 (100)
PAHUnexposed33 (29.2)70 (61.9)0.43710 (8.8)113 (100)
Exposed4 (44.4)4 (44.4)1 (11.1)9 (100)
ChromeUnexposed36 (30.0)74 (61.7)0.33310 (8.3)120 (100)
Exposed1 (50.0)0 (0.0)1 (50.0)2 (100)
DieselUnexposed36 (30.3)72 (60.5)1.011 (9.2)119 (100)
Exposed1 (33.3)2 (66.7)0 (0.0)3 (100)
PaintsUnexposed35 (29.2)74 (61.7)0.10911 (9.2)120 (100)
Exposed2 (100.0)0 (0.0)0 (0.0)2 (100)
SilicaUnexposed36 (30.5)72 (61.0)1.010 (8.5)118 (100)
Exposed1 (25.0)2 (50.0)1 (25.0)4 (100)

Data are presented as n (%), unless otherwise stated. NOS: not otherwise specified; PAH: polycyclic aromatic hydrocarbons. #: L858R/L861Q/P848L/Exon 21 subst. NOS; : Del 19/Exon 19 NOS.