Distribution of EGFR mutation type (substitution in exon 21/deletion in exon 19/other or NOS) in relation to occupational exposure
| Agent | Exposure | EGFR mutation type | Total | |||
| Substitution in Exon 21# | Deletion in Exon 19¶ | p-value exon 21 versus 19 (Fisher) | Other/NOS | |||
| Asbestos | Unexposed | 35 (29.7) | 72 (61.0) | 0.6 | 11 (9.3) | 118 (100) |
| Exposed | 2 (50.0) | 2 (50.0) | 0 (0.0) | 4 (100) | ||
| PAH | Unexposed | 33 (29.2) | 70 (61.9) | 0.437 | 10 (8.8) | 113 (100) |
| Exposed | 4 (44.4) | 4 (44.4) | 1 (11.1) | 9 (100) | ||
| Chrome | Unexposed | 36 (30.0) | 74 (61.7) | 0.333 | 10 (8.3) | 120 (100) |
| Exposed | 1 (50.0) | 0 (0.0) | 1 (50.0) | 2 (100) | ||
| Diesel | Unexposed | 36 (30.3) | 72 (60.5) | 1.0 | 11 (9.2) | 119 (100) |
| Exposed | 1 (33.3) | 2 (66.7) | 0 (0.0) | 3 (100) | ||
| Paints | Unexposed | 35 (29.2) | 74 (61.7) | 0.109 | 11 (9.2) | 120 (100) |
| Exposed | 2 (100.0) | 0 (0.0) | 0 (0.0) | 2 (100) | ||
| Silica | Unexposed | 36 (30.5) | 72 (61.0) | 1.0 | 10 (8.5) | 118 (100) |
| Exposed | 1 (25.0) | 2 (50.0) | 1 (25.0) | 4 (100) | ||
Data are presented as n (%), unless otherwise stated. NOS: not otherwise specified; PAH: polycyclic aromatic hydrocarbons. #: L858R/L861Q/P848L/Exon 21 subst. NOS; ¶: Del 19/Exon 19 NOS.