TABLE 4

Binary logistic regression analysis in univariate and adjusted models for biomarker mutation occurrence in relation to occupational exposure (binary variable)#

BiomarkerOccupational exposureCrude OR(95% CI)p-valueAOR(Lower 95% CI)p-value
EGFRPAH1.032(0.437–2.436)0.9421.340(0.533–3.369)0.533
Asbestos0.313(0.102–0.960)0.0420.376(0.118–1.201)0.099
Silica0.582(0.175–1.933)0.3770.703(0.197–2.515)0.588
DEF1.347(0.267–6.786)0.7182.541(0.392–16.463)0.328
Chrome0.891(0.147–5.411)0.9001.011(0.156–6.536)0.991
Paint0.891(0.147–5.411)0.9000.875(0.141–5.421)0.886
HER2PAH2.214(0.248–19.799)0.4771.644(0.153–17.656)0.681
Asbestos5.778(1.019–32.775)0.0485.089(0.732–35.395)0.100
Silica4.571(0.469–44.538)0.1913.297(0.239–45.395)0.373
Chrome11.643(0.940–144.249)0.0567.779(0.488–124.078)0.147
KRASAsbestos0.813(0.102–6.501)0.8450.867(0.102–7.354)0.896
Silica1.209(0.147–9.925)0.8601.363(0.144–12.871)0.787
Paint4.588(0.453–46.507)0.1975.072(0.452–56.942)0.188
BRAFPAH1.259(0.149–10.622)0.8321.136(0.116–11.116)0.913
Asbestos3.308(0.636–17.203)0.1553.411(0.565–20.595)0.181
Silica1.944(0.224–16.895)0.5471.697(0.153–18.855)0.667
DEF6.741(0.636–71.395)0.11311.103(0.507–243.270)0.126
ALKPAH0.830(0.100–6.923)0.864NC

AOR: adjusted odds ratio; PAH: polycyclic aromatic hydrocarbons; DEF: diesel exhaust fumes; NC: not computable. #: for all categories, the unexposed patient group is the reference (not shown). : adjusted for sex (binary), age at diagnosis (continuous), cumulative duration (years) of passive smoking exposure (continuous) and body mass index (continuous). Others are not computable.