TABLE 1

Main demographics, exposure to risk factors, observed mutations, and definite occupational exposure findings in the analysed population

VariableIncluded in the current analysis
Subjects n313
Female sex260 (83.1)
Age at diagnosis69.46±11.46
 Age <55 years36 (12)
 Age >80 years50 (16)
BMI
 Underweight14 (4.5)
 Normal164 (53.1)
 Pre-obese91 (29.4)
 Obese40 (12.9)
Education level
 High school and higher139 (44.8)
 Secondary school69 (22.3)
 Primary school or no schooling102 (32.9)
ETS exposure “yes”206 (66.0)
Cumulative duration of ETS exposure years30.03±21.09
Family history of lung cancer#73 (23.4)
Personal history of cancer57 (18.2)
Patients exposed to solid fuels from heating or cooking for over 50% of his/her lifetime62 (25.7)
Personal history of respiratory disease+46 (14.7)
Personal history of respiratory infection§103 (32.9)
Histology
 Squamous cell carcinoma22 (7.0)
 Adenocarcinoma273 (87.2)
 Other and NOS18 (5.8)
TTF-1 status by immunohistochemistry
 Positive240 (76.7)
 Negative51 (15.3)
 Unknown25 (8.0)
Mutation results
 EGFR127 (42.8)
 KRAS18 (7.1)
 ALK20 (11.7)
 BRAF10 (5.1)
 HER28 (4.6)
 PIK34 (2.5)
TNM 7th edition stage
 Stage I25 (8.1)
 Stage II21 (6.8)
 Stage III36 (11.6)
 Stage IV228 (73.5)
Exposure (definite/probable) to occupational carcinogens
 Asbestos21 (6.7)
 PAH27 (8.6)
 Chrome6 (1.9)
 DEF8 (2.6)
 Paint6 (1.9)
 Silica14 (4.5)
Number of occupational agent exposures per patient
 0273 (87.2)
 119 (6.1)
 29 (2.9)
 34 (1.3)
 47 (2.2)
 51 (0.3)

Data are presented as mean±sd or n (%), unless otherwise stated. BMI: body mass index; ETS: environmental tobacco smoke; NOS: not otherwise specified; TTF-1: thyroid transcription factor-1; TNM: tumour, node, metastasis; PAH: polycyclic aromatic hydrocarbons; DEF: diesel exhaust fumes. #: two or more relatives affected by lung cancer; : at least one case of cancer; +: asthma/emphysema/chronic obstructive pulmonary disease/bronchiectasis; §: pertussis/tuberculosis/pneumonia.