TABLE 2

Association between interstitial lung abnormalities (ILAs) and the MUC5B promoter polymorphism#

ILA subtypeAGES-ReykjavikCOPDGene (non-Hispanic, white)COPDGene (African-American)Cohorts combined
Adjusted OR (95% CI)p-valueAdjusted OR (95% CI)p-valueAdjusted OR (95% CI)p-valueI2+Adjusted OR (95% CI)p-value§ (corrected)
ILA2.7 (2.2, 3.2)1×10−221.6 (1.3, 2.0)2×10−61.5 (0.8, 2.8)0.1981%2.1 (1.8, 2.4)1×10−26
ILA without fibrosisƒ2.3 (1.8, 2.9)5×10−131.5 (1.2, 1.9)0.00040.99 (0.5, 2.2)0.9776%1.8 (1.5, 2.1)2×10−12
Definite fibrosis3.3 (2.4,4.4)5×10−152.1 (1.4, 3.1)0.00016.2 (2.3, 16.8)0.000359%3.0 (2.4, 3.7)8×10−22
Centrilobular1.3 (0.7, 2.5)0.440.64 (0.4, 1.1)0.091.2 (0.4, 3.8)0.7915%0.91 (0.63, 1.3)1.0
Subpleural3.0 (2.3, 3.7)2×10−192.4 (1.9, 3.2)5×10−112.3 (0.98, 5.4)0.060%2.6 (2.2, 3.1)1×10−30
Mixed2.3 (1.6, 3.3)2×10−51.05 (0.6, 1.7)0.861.06 (0.3, 3.4)0.9366%1.5 (1.1, 2.0)0.05
Radiologic ILD##4.4 (2.2, 9.0)4×10−54.8 (2.5, 8.9)1×10−60%4.4 (2.8, 6.8)5×10−10
Inconsistent with UIP¶¶2.2 (1.7, 3.0)1×10−70.95 (0.7, 1.3)0.751.0 (0.4, 2.4)0.9455%1.4 (1.1, 1.7)0.01
Possible UIP2.8 (2.2, 3.6)9×10−172.5 (1.9, 3.3)1×10−112.7 (1.1, 6.3)0.031%2.7 (2.3, 3.2)1×10−30
UIP4.4 (2.2, 9.0)4×10−54.6 (2.0, 10.4)0.00030%4.1 (2.1, 8.1)0.0003

#: analyses of the MUC5B genotype were performed using additive genetic models; odds ratios are per copy of the MUC5B minor allele; : models are adjusted for age, sex and tobacco exposure; +: I2 calculated using the DerSimonian and Laird method; §: p-value corrected for multiple testing using Bonferroni correction; ƒ: fibrosis is evidence of pulmonary parenchymal architectural distortion; ##: analysis was not done in African-Americans; no participants with radiologic interstitial lung disease (ILD) had the MUC5B genotype; ¶¶: analysis was not done in African-Americans; no participants with usual interstitial pneumonia (UIP) had the MUC5B genotype. AGES: Age Gene/Environment Susceptibility.