TABLE 4

Crude and adjusted models for the association between body mass index (BMI) and bronchial hyperresponsiveness

Model 1
OR (95% CI)
Model 2
OR (95% CI)
BMI1.05** (1.01–1.09)#1.17** ([1.05–1.31)
1.05 (0.98–1.13)
+0.99 (0.93–1.04)
Interaction term
 BMI×remitted asthma0.90 (0.79–1.02); p=0.10
 BMI×current asthma0.84 (0.71–0.95); p=0.006
Never asthma
Remitted asthma
Current asthma
Female sex3.69*** (2.18–6.26)
Atopy2.40*** (1.38–4.16)
 Never smoker1.00
 Former smoker1.11 (0.60–2.04)
 Current smoker1.74 (0.88–3.42)
Socioeconomic status
 Level 11.00
 Level 21.03 (0.43–2.48)
 Level 30.86 (0.42–1.78)
 Level 41.02 (0.46–2.26)
 Level 5 (lowest)2.17* (1.07–4.41)
ICS use1.05 (0.57–1.96)
Baseline FEV1/FVC ratio0.86*** (0.81–0.91)
Family history of asthma
 Neither parent1.00
 Either or both parents1.21 (0.66–2.24)
Observations683628

*: p<0.05; **: p<0.01; ***: p<0.001. #: estimate for a 1-unit increase in BMI for “never asthma”; : estimate for a 1-unit increase in BMI for “remitted asthma”; +: estimate for a 1-unit increase in BMI for “current asthma”. ICS: inhaled corticosteroid; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity.