TABLE 3

Comparison of adjusted hazard ratios of death for PiZZ individuals and control subjects (n=5999) in separate analyses stratified by smoking habits, gender and respiratory symptoms

PiZZ subjects versus controlsAll PiZZ subjectsPiZZ subjects identified by screening
HR (95% CI)p-valueHR (95% CI)p-value
Ever-smokers#3.4 (2.9–4.0)<0.0013.0 (2.1–4.3)<0.001
Never-smokers#2.6 (2.2–3.2)<0.0011.2 (0.6–2.2)NS
Males3.3 (2.8–3.9)<0.0012.1 (1.4–3.2)<0.001
Females3.0 (2.5–3.6)<0.0012.4 (1.5–3.7)<0.001
With respiratory symptoms+3.8 (3.2–4.4)<0.0013.1 (2.2–4.4)<0.001
Without respiratory symptoms+2.2 (1.7–2.9)<0.0011.1 (0.6–2.1)NS

Analyses were performed for all 1585 PiZZ subjects and 375 PiZZ subjects identified by screening. #versus ever- and never-smokers in controls, adjusted for age, gender, date of inclusion and respiratory symptoms. : adjusted for age, smoking habits, date of inclusion and respiratory symptoms. +: adjusted for age, gender, date of inclusion and smoking habits.