TABLE 3

MUC5B genotype and prediction of interstitial lung abnormality#

MUC5B minor alleleClinical dataClinical data+MUC5B minor allelep-value for the comparison of clinical with Clinical+MUC5B
C-statistic (95% CI)p-valueC-statistic (95% CI)p-valueC-statistic (95% CI)p-value
AGES-Reykjavik
 ILA0.61 (0.59, 0.64)<0.00010.64 (0.61, 0.66)<0.00010.72 (0.69, 0.74)<0.0001<0.0001
 Subpleural and radiologic ILD0.63 (0.60, 0.67)<0.00010.66 (0.63, 0.70)<0.00010.72 (0.69, 0.76)<0.0001<0.0001
 Definite fibrosis+0.64 (0.60, 0.69)<0.00010.70 (0.65, 0.75)<0.00010.75 (0.70, 0.79)<0.00010.004
 Possible UIP and UIP0.64 (0.61, 0.67)<0.00010.64 (0.61, 0.68)<0.00010.72 (0.69, 0.75)<0.00010.001
Non-Hispanic white subjects in COPDGene
 ILA0.54 (0.52, 0.62)<0.00010.57 (0.55, 0.60)<0.00010.58 (0.56, 0.61)<0.00010.20
 Subpleural and radiologic ILD0.60 (0.57, 0.63)<0.00010.72 (0.69, 0.75)<0.00010.75 (0.72, 0.78)<0.00010.0006
 Definite fibrosis0.57 (0.52, 0.62)<0.00010.76 (0.71, 0.80)<0.00010.76 (0.72, 0.81)<0.00010.22
 Possible UIP and UIP0.60 (0.57, 0.63)<0.00010.71 (0.68, 0.75)<0.00010.75 (0.72, 0.78)<0.00010.0008
African-Americans in COPDGene
 ILA0.51 (0.49, 0.52)0.30.58 (0.54, 0.62)0.00060.59 (0.55, 0.62)0.00010.52
 Subpleural and radiologic ILD0.52 (0.49, 0.55)0.10.67 (0.62, 0.74)<0.00010.59 (0.55, 0.62)<0.00010.47
 Definite fibrosis0.58 (0.50, 0.65)0.00050.67 (0.62, 0.74)<0.00010.73 (0.62, 0.85)0.0050.34
 Possible UIP and UIP0.52 (0.49, 0.56)0.060.69 (0.63, 0.77)<0.00010.70 (0.63, 0.76)<0.00010.50

#: analyses using the MUC5B genotype were performed using additive genetic models; : clinical data includes age, sex and pack-years of tobacco exposure; +: definite fibrosis is evidence of pulmonary parenchymal architectural distortion. AGES: Age Gene/Environment Susceptibility; ILA: interstitial lung abnormality; ILD: interstitial lung disease; UIP: usual interstitial pneumonia.