TABLE 4

Univariable and multivariable Cox regression analysis of low-risk criteria assessed at first re-evaluation in the subset of patients with available brain natriuretic peptide (BNP) or N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements

Univariable analysisMultivariable analysis
Hazard ratio (95% CI)p-valueHazard ratio (95% CI)p-value
WHO/NYHA FC I–II0.28 (0.19–0.42)<0.0010.47 (0.32–0.71)<0.001
6-min walking distance >440 m0.17 (0.09–0.31)<0.0010.32 (0.17–0.60)<0.001
BNP <50 ng·L−1 or
NT-proBNP <300 ng·mL−1
0.21 (0.13–0.34)<0.0010.31 (0.19–0.52)<0.001
Right atrial pressure <8 mmHg0.45 (0.31–0.65)<0.001
Cardiac index ≥2.5 L·min−1·m−20.44 (0.30–0.65)<0.001

WHO: World Health Organization; NYHA: New York Heart Association; FC: functional class.