Change in functional class (FC), exercise capacity and haemodynamics between baseline and first re-evaluation
| Baseline | First re-evaluation# | p-value | |
| WHO/NYHA FC | |||
| I–II | 261 (26) | 595 (59) | <0.001 |
| III | 624 (61) | 349 (34) | |
| IV | 132 (13) | 73 (7) | |
| 6-min walking distance m | 311±145 | 354±145 | <0.001 |
| Haemodymamics | |||
| RAP mmHg | 8.6±5.0 | 7.5±4.8 | <0.001 |
| mPAP mmHg | 50±13 | 44±13 | <0.001 |
| Cardiac output L·min−1 | 4.4±1.4 | 5.3±1.6 | <0.001 |
| Cardiac index L·min−1·m−2 | 2.4±0.7 | 2.9±0.8 | <0.001 |
| PVR Wood units | 10.5±5.9 | 7.1±4.6 | <0.001 |
| SvO2 % | 63±10 | 67±8 | <0.001 |
Data are presented as n (%) or mean±sd, unless otherwise stated. n=1017. WHO: World Health Organization; NYHA: New York Heart Association; RAP: right atrial pressure; mPAP: mean pulmonary artery pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation. #: 5.6±3.4 months after baseline.