TABLE 2

Univariable and multivariable Cox regression analysis of low-risk criteria assessed at baseline and first re-evaluation

Univariable analysisMultivariable analysis
Hazard ratio (95% CI)p-valueHazard ratio (95% CI)p-value
At baseline
 WHO/NYHA FC I–II0.59 (0.43–0.82)0.001
 6-min walking distance >440 m0.29 (0.18–0.46)<0.0010.31 (0.19–0.50)<0.001
 Right atrial pressure <8 mmHg0.71 (0.55–0.92)0.009
 Cardiac index ≥2.5 L·min−1·m−20.76 (0.59–0.97)0.029
At first re-evaluation
 WHO/NYHA FC I–II0.30 (0.23–0.39)<0.0010.44 (0.34–0.58)<0.001
 6-min walking distance >440 m0.24 (0.17–0.34)<0.0010.37 (0.26–0.55)<0.001
 Right atrial pressure <8 mmHg0.51 (0.40–0.64)<0.0010.74 (0.57–0.94)0.016
 Cardiac index ≥2.5 L·min−1·m−20.51 (0.40–0.65)<0.0010.64 (0.50–0.82)<0.001

WHO: World Health Organization; NYHA: New York Heart Association; FC: functional class.