TABLE 1

Demographics and baseline characteristics of overall and study populations of patients with newly diagnosed idiopathic, heritable and drug-induced pulmonary arterial hypertension (PAH)

Overall populationStudy population
Subjects15911017
Female/male924 (58)/667 (42)598 (59)/419 (41)
Age years60±1757±17
BMI kg·m−227.8±7.027.7±6.4
BMI >30 kg·m−2474 (30)291 (29)
PAH diagnosis
 Idiopathic1228 (77)762 (75)
 Heritable109 (7)94 (9)
 Drug-induced254 (16)161 (16)
Acute vasodilator responder139 (8.7)97 (9.5)
WHO/NYHA functional class
 I–II441 (28)261 (26)
 III925 (58)624 (61)
 IV225 (14)132 (13)
6-min walking distance m307±142311±145
Haemodynamics
 RAP mmHg8.8±5.28.6±5.0
 mPAP mmHg48±1350±13
 PAWP mmHg10±49±4
 Cardiac output L·min−14.4±1.54.4±1.4
 Cardiac index L·min−1·m−22.4±0.82.4±0.7
 PVR Wood units9.9±5.610.5±5.9
 Mean blood pressure mmHg96±1895±17
 Heart rate beats·min-180±1680±15
SvO2 %63±1063±9#

Data are presented as n, n (%) or mean±sd. BMI: body mass index; WHO: World Health Organization; NYHA: New York Heart Association; RAP: right atrial pressure; mPAP: mean pulmonary artery pressure; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation. #: n=606.