TABLE 2

Patient characteristics, pulmonary function tests, cystic fibrosis magnetic resonance imaging score (CF-MRI), diffusion-weighted magnetic resonance imaging (DWI) scores and apparent diffusion coefficient (ADC)

ParametersControlsRTEp-value
Age years18.50 (15–31)21 (17–36)0.3
Males/females n/n12/159/200.2
FEV1 6 months before t085.9±25.469.7±21.70.011*
FVC 6 months before t097.3±14.285.7±14.90.004*
FEV1 at t088.2±17.670.7±19.50.001*
FVC at t098.6±13.381.9±21.80.01*
FEF25–75 at t068.8±31.844.2±23.80.002*
FEV1 at t188.3±18.977.3±19.50.036*
FVC at t196.7±14.286.9±15.60.016*
FEF25–75 at t168.6±33.452.6±27.90.053
PEX at t004.5 (4.1–5.9)<0.001*
PEX at t101.2 (0–1.2)0.1
CF-MRI at t016.2 (11–36)42 (25–61)<0.001*
CF-MRI at t116 (1–34.5)39 (18–56)0.002*
DWI at t07 (0–16.7)22 (9–26)0.002*
DWI at t19 (0–17.7)13 (5–19)0.179
ADC at t0 ×10−3 mm2·s−11.55 (1.49–1.64)1.26 (1.21–1.46)<0.001*
ADC at t1 ×10−3 mm2·s−11.56 (1.48–1.61)1.57 (1.35–1.63)0.9

Data are presented as median (interquartile range) or mean±sd. FEV1: forced expiratory volume in 1 s; FVC: functional vital capacity; FEF25–75: forced expiratory flow at 25–75% of FVC; PEX: pulmonary exacerbation score. *: significant differences between the groups.