TABLE 3

Differences in spirometry, clinical and magnetic resonance imaging (MRI) parameters between baseline and follow-up

ParametersControlsRTE
BaselineFollow-upp-valueBaselineFollow-upp-value
FEV188.2±17.688.3±18.90.97670.7±19.577.3±19.5<0.0001*
FVC98.6±13.396.7±14.20.3381.9±21.886.9±15.6<0.0001*
FEF25–7568.8±31.868.6±33.40.94844.2±23.852.6±27.9<0.0001*
PEX00ns4.5 (4.1–5.9)1.2 (0–1.2)<0.0001*
CF-MRI16.2 (11–36)16 (1–34.5)0.82442 (25–61)39 (18–56)<0.0001*
DWI score7 (0–16.7)9 (0–17.7)0.65222 (9–26)13 (5–19)<0.0001*
ADC ×10−3 mm2·s−11.55 (1.49–1.64)1.56 (1.48–1.61)0.1781.26 (1.21–1.46)1.57 (1.35–1.63)<0.0001*
ROI n1.81±1.61.68±1.49ns3.09±1.52.59±1.7<0.005*
ROI area mm255.36±37.37)58.26±39ns132.7 (90.6–232)76.9 (50.2–162.7)<0.0001*

Data are presented as median (interquartile range) or mean±sd. FEV1: forced expiratory volume in 1 s; FVC: functional vital capacity; FEF25–75: forced expiratory flow at 25–75% of FVC; PEX:pulmonary exacerbation score; CF-MRI:cystic fibrosis magnetic resonance imaging score; DWI score: diffusion-weighted magnetic resonance imaging total score; ADC:apparent diffusion coefficient expressed as 10−3 mm2·s−1; ROI: region of interest. *: significant differences.