Main analysis | Sensitivity analysis^{#} | |||||

Number of studies | RR (95% CI) | Heterogeneity Chi-squared and I^{2} | Number of studies | RR (95% CI) | Heterogeneity Chi-squared and I^{2} | |

All studies | 15 | 1.35 (1.09–1.68) | 82.49 (df=14; p=0.00) and 83.00% | 19 | 1.50 (1.22–1.84) | 118.45 (df=18; p=0.00) and 84.8% |

All studies (including studies with drinkers in reference category) | 20 | 1.50 (1.23–1.83) | 110.91 (df=19; p=0.00) and 82.90% | 24 | 1.60 (1.32–1.94) | 146.25 (df=23; p=0.00) and 84.3% |

Study design | ||||||

Case–control | 12 | 1.35 (1.00–1.81) | 60.94 (df=11; p=0.00) and 81.90% | 16 | 1.53 (1.17–1.99) | 85.30 (df=15; p=0.00) and 82.4% |

Cohort | 3 | 1.49 (0.90–2.46) | 8.57 (df=2; p=0.01) and 76.70% | 3 | 1.49 (0.90–2.46) | 8.57 (df=2; p=0.01) and 76.7% |

Confounding | ||||||

Adjusted for any confounder | 11 | 1.47 (1.16–1.88) | 60.14 (df=10; p=0.00) and 83.40% | 13 | 1.46 (1.18–1.81) | 63.07 (df=12; p=0.00) and 81.0% |

Adjusted for age | 9 | 1.34 (1.05–1.72) | 41.33 (df=8; p=0.00) and 80.60% | 10 | 1.33 (1.07–1.66) | 42.43 (df=9; p=0.00) and 78.8% |

Adjusted for age and others | 8 | 1.27 (0.99–1.64) | 33.05 (df=7; p=0.00) and 78.80% | 9 | 1.27 (1.01–1.59) | 34.22 (df=8; p=0.00) and 76.6% |

Tuberculosis burden in study country of origin | ||||||

High tuberculosis burden countries | 5 | 1.56 (1.27–1.91) | 6.35 (df=4; p=0.18) and 37.00% | 7 | 1.51 (1.30–1.76) | 7.25 (df=6; p=0.30) and 17.2% |

Non-high tuberculosis burden countries | 10 | 1.25 (0.91–1.70) | 53.43 (df=9; p=0.00) and 83.20% | 12 | 1.49 (1.07–2.06) | 87.79 (df=11; p=0.00) and 87.5% |

Problem drinking in study country of origin | ||||||

Problem-drinking countries | 9 | 1.51 (1.12–2.03) | 61.05 (df=8; p=0.00) and 86.90% | 10 | 1.48 (1.13–1.92) | 62.04 (df=9; p=0.00) and 85.5% |

Non-problem-drinking countries | 6 | 1.19 (0.81–1.76) | 21.42 (df=5; p=0.00) and 76.70% | 9 | 1.58 (1.04–2.40) | 52.10 (df=8; p=0.00) and 84.6% |

df: degrees of freedom. ^{#}: includes studies with unclear temporal relationships between exposure and outcome.