TABLE 2

Sample size estimates to achieve 80% power, comparing intermittent and repeated measures

OutcomeEffect size %Measurement frequency
Weekly×24Weeks 1 and 24
FVC; assumed control change of −50 mL20594624 002
3519427837
509513840
FVC; assumed control change of −100 mL2014876000
354851959
50238960
FVC; assumed control change of −150 mL206612667
35216871
50106427
UCSD-SOBQ2017781731
35581565
50285277
Dyspnoea VAS2051224993
3516721630
50819799

FVC: forced vital capacity; UCSD-SOBQ: University of California, San Diego Shortness of Breath Questionnaire; VAS: visual analogue score.