TABLE 4

Treatment outcomes of 428 culture-confirmed multidrug resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) patients exposed to bedaquiline-containing regimens in different settings and stratified by cohort

AfricaEastern EuropeOther settings2008–20092010–20112012–2014
Total cohort11385499121
 Success73 (64.6)65 (76.5)38 (77.6)5 (55.6)95 (78.5)
 Cure73 (64.6)54 (63.5)27 (55.1)5 (55.6)81 (66.9)
 Completion11 (12.9)11 (22.5)0 (0.0)14 (11.6)
 Death27 (23.9)3 (3.5)3 (6.1)2 (22.2)6 (5.0)
 Default9 (8.0)8 (9.4)1 (2.0)2 (22.2)4 (3.3)
 Failure3 (2.7)9 (10.6)7 (14.3)0 (0.0)16 (13.2)
 Transfer out1 (0.9)
MDR-TB623927
 Success36 (58.1)28 (71.8)22 (81.5)
 Cure36 (58.1)20 (51.3)11 (40.7)
 Completion8 (20.5)11 (40.7)
 Death17 (27.4)3 (7.7)1 (3.7)
 Default7 (11.3)3 (7.7)1 (3.7)
 Failure1 (1.6)5 (12.8)3 (11.1)
 Transfer out1 (1.6)
XDR-TB514622
 Success37 (72.6)37 (80.4)16 (72.7)
 Cure37 (72.6)34 (73.9)16 (72.7)
 Completion3 (6.5)
 Death10 (19.6)2 (9.1)
 Default2 (3.9)5 (10.9)
 Failure2 (3.9)4 (8.7)4 (18.2)
 Transfer out
  • Data are presented as n or n (%).