TABLE 2

Results of the meta-analysis of genome-wide association studies of asthma in Puerto Ricans, for single nucleotide polymorphisms associated with asthma in two previous meta-analysis in Europeans (by the GABRIEL consortium) and ethnically diverse North Americans (by the EVE consortium)

SNPChrPositionRefAltGeneIn cited paperHartford-PRGALA IGALA IIHCHS/SOLCombined
ORAAFORp-valueAAFORp-valueAAFORp-valueAAFORp-valueORp-value
Loci reported by the GABRIEL consortium [4]
 rs37711662102 986 222GAIL18R10.85#0.450.900.5000.440.750.1140.430.850.0180.461.140.1100.940.111
 rs9273349632 625 869AGHLA-DQ1.14#0.610.980.860NANANANANANA0.621.220.0161.130.079
 rs134232696 190 076ACIL331.27#0.210.900.4030.261.120.5710.221.050.5280.201.130.2131.050.376
 rs7449101567 446 785GASMAD30.89#0.430.880.1750.421.010.9810.450.930.2690.451.050.5720.950.326
 rs23054801738 062 196GAGSDMB0.76#0.310.622.0×1060.310.540.0030.320.716.7×1060.340.860.0710.727.4×1012
 rs38941941738 121 993GAGSDMA1.26#0.371.230.0340.390.920.6480.401.230.0020.390.940.4061.110.023
 rs22840332237 534 034GAIL2RB0.92#0.410.910.2720.391.090.6380.401.170.0240.421.000.9971.040.289
 rs20736435131 723 288TCSLC22A50.89#0.500.960.6680.481.180.3560.500.930.2570.511.010.8560.980.551
 rs12956865131 995 843TCIL130.85#0.591.010.9430.620.750.1360.620.900.1590.611.070.3980.960.408
 rs110715591561 069 988CTRORA0.88#0.261.070.5250.251.690.0120.240.900.1930.240.850.0870.960.486
Replicated genes reported by the EVE consortium [3]
 rs11020001158 932 907TCPYHIN10.760.081.090.6510.060.500.061NANANA0.071.210.9860.930.611
 rs101730812102 957 348CTIL1RL10.830.190.840.1320.160.850.5190.260.780.0100.180.930.5060.840.004
 rs18372535110 401 872CTTSLP0.840.250.730.0040.230.650.0410.270.830.0140.260.960.7010.822.5×104
 rs238141696 193 455ACIL331.180.380.980.8470.391.000.9800.371.090.2490.351.130.1571.070.155
 rs110789271738 064 405CTGSDMB0.790.300.611.4×1060.310.550.0030.310.717.9×1060.340.860.0790.728.1×1012

GABRIEL: A Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community; EVE: A Study to Identify Asthma-susceptibility Genes in Ethnically Diverse Populations; Ref: reference allele; Alt: alternative allele; AAF: alternative allele frequency. Human Genome version: hg19. #: childhood onset odds ratio [4]; : overall odds ratio [3].