TABLE 2

Prevalence of asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) in the total weighted study population and asthma/COPD subpopulation according to different ACOS definitions

Total populationAsthma/COPD population
Subjects n5675846
ACOS definition
 1) COPD AND Asthma in registry1.210.3
 2) COPD AND Asthma in registry OR ACOS as text in EMR1.210.3
 3) Self-reported COPD AND Asthma0.54.4
 4) FEV1/FVC <0.7 AND at least 10 pack-years AND  asthma before 40 years of age0.64.7
 5) COPD in registry OR Self-reported AND FEV1/FVC <0.7  AND Asthma in registry OR Self-reported1.19.2
 6) COPD in registry OR Self-reported OR FEV1/FVC <0.7  AND Asthma in registry OR Self-reported OR FeNO  ≥45 ppb4.938.3

All values are expressed as weighted proportion (%), unless otherwise stated. EMR: electronic medical record; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FeNO: exhaled nitric oxide fraction.