TABLE 1

Nationwide resistance to the drugs composing the World Health Organization “shorter” regimen in Brazil, 2000–2015

Drug tested2000–20102011–2015p-valueOverall 2000–2015
Resistant/tested nResistant % (95% CI)Resistant/tested nResistant % (95% CI)Resistant/tested nResistant % (95% CI)
Pyrazinamide1025/198951.5 (44.3–53.7)449/96146.7 (43.6–49.9)0.011474/295050.0 (48.2–51.8)
Ethambutol1177/310337.9 (36.2–39.6)934/330528.3 (26.8–29.8)<0.00012111/640832.9 (31.8–34.1)
Fluoroquinolones#30/10030.0 (21.0–39.0)339/97234.9 (31.9–37.9)0.33369/107234.4 (31.6–37.3)
Levofloxacin2/728.6 (−4.9–62.1)3/1915.8 (−0.6–32.2)0.595/2619.2 (4.1–34.3)
Moxifloxacin2/366.7% (13.4–120.0)8/1942.1 (19.9–64.3)0.5710/2245.5 (24.7–66.3)
Ofloxacin28/9629.2 (20.1–38.3)332/96034.6 (31.6–37.6)0.29360/105634.1 (31.2–37.0)
Amikacin14/8815.9 (8.3–23.5)120/95112.6 (10.5–14.7)0.38134/103912.9 (10.9–14.9)
Kanamycin6/2722.2 (6.5–37.9)106/91411.6 (9.5–13.7)0.09112/94111.9 (9.8–14.0)
Ethionamide464/156429.7 (27.4–32.0)24/12619.1 (12.2–26.0)0.01488/169028.9 26.7–31.0)
  • #: resistance to any fluoroquinolone.