Placebo | Doxycycline | |||||||
Before | After | Change | p-value | Before | After | Change | p-value | |
IL-17 | 4.55±1.86 | 4.16±2.3 | −0.3387±1.9 | 0.313 | 4.24±2.00 | 3.44±1.68 | −0.807±3.01 | 0.365 |
IL-1α | 238.8±207 | 290.2±282 | 51.4±169 | 0.525 | 271±202 | 270±237 | −0.737±308 | 0.920 |
IL-1β | 2687±1822 | 1340±1362 | −1347±1750 | 0.005 | 2105±1483 | 1135±1297 | −970±1648 | 0.038 |
IL-6 | 5.75±7.13 | 11.3±18.5 | 5.54±19.3 | 0.737 | 6.95±9.96 | 9.22±10.9 | 2.27±14.4 | 0.615 |
MIP-1α | 56.9±29.6 | 52.5±39.0 | −4.46±30.6 | 0.489 | 66.5±62.0 | 53.2±39.8 | −13.3±77.4 | 0.514 |
TNF-α | 118±97.8 | 75.0±78.1 | −42.5±87.5 | 0.115 | 126±93.0 | 123±200 | −2.30±203 | 0.220 |
Data are presented as mean±sd. IL: interleukin; MIP: macrophage inflammatory protein; TNF: tumour necrosis factor.