TABLE 2

Dose adjustments of the main chemotherapies for lung cancer in cases of liver dysfunction

AgentHepatic enzymes levelDosage
DocetaxelNormal75 mg·m−2 every 3 weeks
Bilirubin >NNot recommended
AST-ALT >1.5×NNot recommended
AP >2.5×NNot recommended
ErlotinibNormal150 mg·day−1
AST-ALT >3×N50% reduction
Bilirubin >N50% reduction
EtoposideNormal100–120 mg·m−2on D1, D2, D3 every 3 weeks
Bilirubin >1.25–2.5×N50% reduction
Bilirubin >2.5×NNot recommended
GemcitabineNormal1000–1250 mg·m−2
AST-ALT-bilirubin >1–3×N800 mg·m−2
IrinotecanNormal350 mg·m−2 every 3 weeks
Bilirubin >1.5–3×N200 mg·m−2 every 3 weeks
Bilirubin >3–5×NNot recommended
PaclitaxelNormal175–200 mg·m−2 every 3 weeks
AST-ALT >N135 mg·m−2 every 3 weeks
Bilirubin >1.25–2×N115 mg·m−2 every 3 weeks
Bilirubin >2–3.5×N100 mg·m−2 every 3 weeks
Bilirubin >3.5×NNot recommended
VinorelbineNormal25–30 mg·m−2 per week
Bilirubin >1.75–2.5×N50% reduction
Bilirubin >2.5×N75% reduction
  • ALT: alanine aminotransferase; AST: aspartate aminotransferase; N: normal level.