TABLE 1

Association of sputum culture conversion status with treatment outcome (success versus failure or death)

Month of treatment#Failure/deathSuccessOdds ratio (95% CI)p-valueSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)
2 months33.3 (23.4–44.5)80.0 (67.0–89.6)71.8 (55.1–85.0)44.0 (34.1–54.3)
 Did not convert44 (80.0)56 (66.7)1 (reference)
 Converted11 (20.0)28 (33.3)2.0 (0.9–4.5)0.087
3 months52.4 (41.2–63.4)70.9 (57.1–82.4)73.3 (60.3–83.9)49.4 (37.9–60.9)
 Did not convert39 (70.9)40 (47.6)1 (reference)
 Converted16 (29.1)44 (52.4)2.7 (1.3–5.5)0.007
6 months90.5 (82.1–95.8)56.4 (42.3–69.7)76.0 (66.4–84.0)79.5 (63.5–90.7)
 Did not convert31 (56.4)8 (9.5)1 (reference)
 Converted24 (43.6)76 (90.5)12.3 (5.0 –30.3)<0.001
24 months95.2 (88.3–98.7)52.7 (38.8–66.3)75.5 (66.2–83.3)87.9 (71.8–96.6)
 Did not convert29 (52.7)4 (4.8)1 (reference)
 Converted26 (47.3)80 (95.2)22.3 (7.2–69.4)<0.001
  • Data are presented as n (%), unless otherwise stated. #: sputum culture conversion was defined as two consecutive negative cultures after the first sputum sample, collected at least 30 days apart. PPV: positive predictive value; NPV: negative predictive value.