What are the most important outcomes to consider when making decisions on the treatment of drug-resistant tuberculosis (TB)?
Outcomes | Mean score |
Adherence to TB treatment (treatment interruption due to nonadherence) | 6.8 |
Avoiding adverse reactions from TB drugs | 7.0 |
Avoiding the acquisition or amplification of drug resistance | 7.9 |
Cure or successful completion by end of treatment | 9.0 |
Culture conversion by month 6 | 7.4 |
Death (survival) by the end of projected treatment | 8.1 |
Treatment failure | 8.7 |
Relapse | 7.7 |
Members of the Guideline Development Group scored TB outcomes according to their relative priority when making decisions on drug-resistant TB treatment. They were asked to take a societal perspective in rating the outcomes. 1–3 points: not important for making recommendations on drug-resistant TB treatment; 4–6 points: important but not critical for making recommendations on drug-resistant TB treatment; 7–9 points: critical for making recommendations on drug-resistant TB treatment.