Outcome of the 2016 call [3] to establish European Reference Networks (ERNs), as approved by the European Commission's Board of Member States on December 15 2016
| Network | Focus |
| ERN BOND | ERN on rare bone disorders |
| ERN CRANIO | ERN on rare craniofacial anomalies and ENT disorders |
| Endo-ERN | ERN on rare endocrine conditions |
| ERN EpiCARE | ERN on rare and complex epilepsies |
| ERKNet | European rare kidney diseases reference network |
| ERN RND | ERN on rare neurological diseases |
| ERNICA | ERN on rare inherited and congenital anomalies |
| ERN-LUNG | ERN on rare respiratory diseases |
| ERN Skin | ERN on rare and undiagnosed skin disorders |
| ERN EURACAN | ERN on rare adult cancers (solid tumours) |
| ERN EuroBloodNet | ERN on rare haematological diseases |
| ERN EURO-NMD | ERN for rare neuromuscular diseases |
| ERN EYE | ERN on rare eye diseases |
| ERN GENTURIS | ERN on genetic tumour risk syndromes |
| ERN GUARD-HEART | ERN on uncommon and rare diseases of the heart |
| ERN ITHACA | ERN on rare congenital malformations and rare intellectual disabilities |
| MetabERN | ERN for rare hereditary metabolic disorders |
| ERN PaedCan | ERN for paediatric cancer (haemato-oncology) |
| ERN RARE-LIVER | ERN on rare hepatological diseases |
| ERN ReCONNET | Rare connective tissue and musculoskeletal diseases network |
| ERN RITA | Rare immunodeficiency, autoinflammatory and autoimmune diseases network |
| ERN TRANSPLANT-CHILD | ERN on transplantation in children |
| VASCERN | ERN on rare multisystemic vascular diseases |
ENT: ear, nose and throat.