TABLE 2

Cox analysis for mortality

VariablenHR95% CIp-value
Demographics
 Age6431.021.00–1.040.005
 Male6471.370.99–1.900.056
 BMI4690.920.88–0.96<0.001
 Smoking5791.641.15–2.350.006
Co-morbidities
 Gastro-oesophageal reflux disease5661.140.83–1.550.427
 Pulmonary hypertension5291.310.89–1.940.173
 COPD5521.330.97–1.830.078
 Obstructive sleep apnoea5621.120.73–1.730.607
 Heart disease5691.020.72–1.430.919
 Diabetes mellitus5680.920.62–1.340.657
 Lung cancer5660.880.12–6.290.898
Physiology#
 FVC % pred4650.670.61–0.74<0.001
DLCO % pred4160.580.51–0.67<0.001
 6MWT SpO2 at rest2040.870.81–0.94<0.001
 6MWT SpO2 nadir1730.940.91–0.98<0.001
 6MWT distance+1840.740.67–0.82<0.001
 CPI4122.171.80–2.61<0.001
 GAP stage4124.643.33–6.47<0.001
Patient reported outcome measures
 St George's Respiratory questionnaire5681.031.02–1.04<0.001
 UCSD shortness of breath questionnaire5741.031.02–1.03<0.001
 Anxiety score5671.020.99–1.060.214
 Depression score5671.111.07–1.16<0.001
 Cough severity5091.011.00–1.140.030
  • Data in bold are statistically significant. BMI: body mass index; COPD: chronic obstructive pulmonary disease; FVC: forced vital capacity; DLCO: diffusion capacity for carbon monoxide; 6MWT: 6-min walk test; SpO2: arterial oxygen saturation measured by pulse oximetry; CPI: composite physiological index; GAP: gender, age, physiology. #: model adjusted for age, gender, BMI and smoking status with n indicating participants with results for all variables included in the model; : every 10 unit change; +: every 50 m change.