Logistic regression analysis of mean pulmonary artery pressure in highlanders
| Dependent variable# | Univariate analysis | Multivariable model | ||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Total AHI events·h−1 | 1.064 | 1.040–1.089 | <0.001 | 1.035 | 1.009–1.062 | 0.008 |
| Time in bed with SpO2 <90% | 1.032 | 1.019–1.045 | <0.001 | 1.016 | 1.001–1.032 | 0.043 |
| Age years | 1.119 | 1.076–1.164 | <0.001 | 1.081 | 1.032–1.132 | 0.001 |
| Sex¶ | 0.955 | 0.450–2.026 | 0.905 | 0.821 | 0.335–2.012 | 0.667 |
| FEV1 %predicted | 0.983 | 0.956–1.012 | 0.259 | |||
| Body mass index kg·m−2 | 1.243 | 1.136–1.360 | <0.001 | 1.041 | 0.933–1.161 | 0.473 |
| ACE I/I+ n | 0.998 | 0.549–1.812 | 0.994 | |||
| eNOS 4a/4a+ n | 1.395 | 0.574–3.391 | 0.463 | |||
| eNOS G-894T+ n | 1.990 | 0.776–5.082 | 0.152 | 1.001 | 0.308–3.252 | 0.999 |
| eNOS T-786C+ n | 1.929 | 0.874–4.258 | 0.104 | 2.646 | 1.022–6.850 | 0.045 |
| MTHTR C-677T+ n | 1.507 | 0.771–2.949 | 0.231 | |||
90 observations at 3250 m (n=83 for genetic analyses). Independent variables with p-value <0.2 in the univariate analysis and gender were included into the multivariable analysis. The multivariable model was adjusted for all variables listed, R2 was 0.244, p<0.001. AHI: apnoea–hypopnoea index; SpO2: oxygen saturation; FEV1: forced expiratory volume in 1 s; ACE: angiotensin-converting enzyme gene polymorphism; eNOS: endothelial nitric oxide synthase gene polymorphism; MTHTR: methylenetetrahydrofolate reductase gene polymorphism. #: quintiles of mean pulmonary artery pressure; ¶: female=1; male=2.+: genotypes were coded as 1=absence of indicated polymorphism, 2=indicated polymorphism in one allele, 3=indicated polymorphism in two alleles.