Summary of diagnostic accuracy of nasal nitric oxide from measurements in consecutive patients suspected of primary ciliary dyskinesia (PCD)
| First author [ref.] | Study population | Sampling method | Threshold nL·min−1 | Sensitivity (95% CI) | Specificity (95% CI) |
| Marthin [24] | 117 referrals (PCD: n=14) | Breath hold: n=58 | 52.5 | 0.92 (0.62–0.998) | 0.96 (0.85–0.995) |
| Oral exhalation against resistance: n=37 | 72.6 | 1.0 (0.54–1.0) | 0.94 (0.79–0.99) | ||
| Tidal breathing: n=97 | 47.4 | 0.93 (0.66–0.998) | 0.80 (0.69–0.88) | ||
| Leigh [25] | 155 referrals (PCD: n=71; indeterminate: n=84) | Oral exhalation, velum closure: n=155 | 77 | 0.99 (0.92–0.9996) | 0.75 (0.64–0.84) |
| Beydon [22] | 86 referrals: (PCD: n=49; non-PCD: n=37) | Velum closure: n=74 | 82.2 | 0.91 (0.79–0.98) 0.90 (0.78–0.97) | 0.86 (0.68–0.96) 0.97 (0.86–0.999) |
| Tidal breathing (five peaks): n=86 | 40 | ||||
| Jackson [26] | 301 referrals: (PCD: n=34; non-PCD: n=267) | Velum closure (breath hold or oral exhalation): n=301 | 30 | 0.90 (0.74–0.98) | 0.95 (0.90–0.98) |