TABLE 1

Univariate and multivariate Cox analysis exploring the independent association of the studied variables with lung cancer diagnosis in the entire population

	p-value	HR	95% CI
Univariate analysis
Age: for each year	0.74	1.00	0.96–1.04
Sex: male versus female	0.65	0.84	0.41–1.75
Pack–years: for each pack–year	0.001	1.02	1.01–1.03
BMI: for each kg·m⁻²	0.03	0.92	0.85–0.99
Emphysema: yes versus no	0.001	4.11	2.26–7.47
COPD: yes versus no	0.001	4.23	2.34–7.63
Telomere length quartiles
Q1: reference (shortest telomere length)	0.001
Q2 versus Q1	0.85	0.90	0.29–2.79
Q3 versus Q1	0.21	1.86	0.69–4.98
Q4 versus Q1	0.001	4.38	1.79–10.7
Multivariate analysis
Pack–years: for each pack–year	0.015	1.01	1.00–1.02
Emphysema: yes versus no	0.002	2.68	1.42–5.05
COPD: yes versus no	0.001	2.96	1.60–5.49
Telomere length quartiles
Q1: reference (shortest telomere length)	0.001
Q2 versus Q1	0.88	0.92	0.29–2.86
Q3 versus Q1	0.17	1.99	0.74–5.36
Q4 versus Q1	0.003	3.97	1.62–9.72

HR: hazard ratio; BMI: body mass index; COPD: Chronic obstructive pulmonary disease; Q: quartile.