Current randomised controlled trials comparing lobectomy versus sublobar resection
| US CALGB 140503 trial (NCT00499330) [26] | Japanese trial (JCOG0802/WJOG4607L) [27] | |
| Surgical study arm 1 | Lobectomy | Lobectomy |
| Surgical study arm 2 | Limited resection (anatomical segmentectomy or non-anatomical wedge) | Anatomical segmentectomy |
| Eligibility | Peripheral lung nodule ≤2 cm on perioperative CT scan and located in outer third of lung and presumed to be NSCLC | Peripheral NSCLC (suspicion) ≤2 cm (proportion max. diameter of tumour to consolidation >0.5) |
| Primary end-point | DFS | OS |
| Secondary end-points | OS, LR, systemic recurrence rates, PFT, correlation preoperative PET-CT with outcome, false negative rate for PET if nodal metastases; utility of annual follow-up CT | PFT, relapse-free survival, LR, proportion of completion of segmentectomy, LOS, duration chest tube, operation time, blood loss, number of auto-sutures |
| Target recruitment | 1297 patients | 1100 patients |
CT: computed tomography; NSCLC: nonsmall cell lung cancer; DFS: disease-free survival; OS: overall survival; LR: local recurrence; PFT: pulmonary function test; PET: positron emission tomography; LOS: length of stay in hospital.