TABLE 5

Age- and gender-adjusted observed/expected ratios for the underlying cause of death (UCD) when sarcoidosis was a nonunderlying cause of death (NUCD) in females#

45–64 years65–84 years≥85 years
Observed/expected ratio (95% CI)p-valueObserved/expected ratio (95% CI)p-valueObserved/expected ratio (95% CI)p-value
Infectious disease6.23 (2.97–13.07)<0.0012.51 (1.67–3.77)<0.0010.62 (0.28–1.39)0.245
 Tuberculosis74.78 (18.51–302.09)<0.00116.64 (8.31–33.33)<0.00101
 Pneumonia010.52 (0.13–2.08)0.35501
 Other6.13 (2.55–14.74)<0.0012.68 (1.56–4.62)<0.0011.74 (0.78–3.87)0.177
Chronic respiratory disease6.45 (1.61–25.82)0.0082.97 (1.55–5.71)0.0010.94 (0.23–3.76)0.929
Cardiovascular diseases2.07 (1.17–3.64)0.0120.84 (0.65–1.08)0.1690.81 (0.62–1.04)0.1
 Cerebrovascular disease1.22 (0.31–4.89)0.7760.94 (0.59–1.48)0.7760.25 (0.09–0.66)0.005
 Ischaemic heart disease0.75 (0.11–5.32)0.7730.61 (0.33–1.13)0.1160.83 (0.47–1.45)0.507
 Other3.17 (1.65–6.09)0.0010.89 (0.62–1.26)0.511.02 (0.75–1.38)0.906
Neoplasm0.44 (0.25–0.77)0.0040.88 (0.7–1.11)0.2711.72 (1.26–2.34)0.001
 Haematologic malignancy0.69 (0.1–4.89)0.7091.08 (0.56–2.07)0.8285.39 (3.13–9.28)<0.001
 Lung cancer0.42 (0.11–1.68)0.2210.79 (0.35–1.75)0.5553.55 (1.33–9.45)0.011
 Other0.42 (0.22–0.81)0.010.86 (0.66–1.12)0.2691.16 (0.77–1.75)0.467
Renal disease7.84 (1.96–31.37)0.0041.51 (0.63–3.63)0.3551.35 (0.51–3.6)0.546
  • #: for each death certificate that listed sarcoidosis as a NUCD during the period 2002–2011, the UCDs were investigated and the observed/expected ratio was calculated; : statistically significant at p<0.05.