Myositis autoantibodies associated with interstitial lung disease (ILD)
| Autoantibody | Clinical associations |
| Myositis-specific autoantibodies | |
| Anti-tRNA synthetases (Jo-1, PL-7, PL-12, EJ, OJ, KS, Ha, Zo) | PM, DM, anti-synthetase syndrome |
| Anti-Mi-2 | “Classic DM”; lung-sparing |
| Anti-CADM-140 (also known as anti-MDA5) | Clinically amyopathic DM ILD; poor prognosis |
| Myositis-associated antibodies | |
| Anti-Ro/SSA | PM/Sjögren's syndrome overlap; severe ILD |
| Anti-PM/Scl | PM/scleroderma overlap; severe ILD |
| Anti-Ku | PM/scleroderma overlap; severe ILD |
| Anti-U1RNP | PM/SLE overlap; ILD |
MDA5: melanoma differentiation-associated protein 5; PM: polymyositis; DM: dermatomyositis; SLE: systemic lupus erythematosus. Reproduced and modified from [6] with permission.