Comparison of symptoms and clinical signs of acromegaly in non-OSA and moderate-to-severe OSA groups (with insulin-like growth factor I measurement and sleep studies)#
| Symptoms/clinical signs of acromegaly | AHI <15 events·h−1¶ | AHI ≥15 events·h−1 | OR (95% CI) | p-value |
| Patients | 567 | 188 | – | – |
| Enlargement of hands, increased ring size % | 10.7 | 10.1 | 1.07 (0.61–1.88) | 0.81 |
| Enlargement of feet, increased shoe size % | 7.6 | 8.4 | 1.23 (0.65–2.31) | 0.52 |
| Arterial hypertension % | 30.1 | 43.1 | 1.86 (1.30–2.68) | 0.001 |
| Headache, visual field defects % | 36.3 | 22.1 | 0.54 (0.38–0.79) | 0.001 |
| Facial changes, macroglossia % | 11.9 | 19.3 | 1.80 (1.05–3.08) | 0.032 |
| Widely spaced teeth % | 9.9 | 8.2 | 0.82 (0.45–1.47) | 0.50 |
| Diabetes mellitus % | 3.7 | 8.8 | 2.96 (1.30–6.73) | 0.010 |
| Sweats, hyperhidrosis % | 54.8 | 53.8 | 0.91 (0.64–1.28) | 0.57 |
| Joint pain, arthralgia % | 42.2 | 42.7 | 1.32 (0.92–1.88) | 0.13 |
| Fatigue/asthenia % | 76.1 | 69.3 | 0.66 (0.45–0.98) | 0.038 |
| Carpal tunnel syndrome, acroparaesthesia % | 26.4 | 23.5 | 0.87 (0.59–1.30) | 0.51 |
| ≥3 symptoms and comorbidities % | 56.7 | 56.6 | 1.07 (0.74–1.56) | 0.71 |
#: n=755; ¶: the non-OSA group consisted of the patients referred for suspicion of sleep apnoea syndrome, but with a diagnosis of no or only mild OSA (AHI <15 events·h−1). AHI: apnoea–hypopnoea index; IGF-I: insulin-like growth factor I; OSA: obstructive sleep apnoea.