TABLE 4

Multivariable analysis: associations with death within 90 days of biopsy

CasesDeathsUnadjusted OR (95% CI)p-valueAdjusted OR (95% CI)p-value
Sex
 Female1274361.000.0051.00
 Male1546751.75 (1.17–2.63)1.54 (1.02–2.34)0.038
Age group years
 ≤44576101.00<0.001 (ptrend)1.00<0.001 (ptrend)
 45–54636211.93 (0.90–4.14)1.72 (0.79–3.72)
 55–64843312.16 (1.05–4.44)1.85 (0.89–3.82)
 65–74588323.26 (1.59–6.69)2.81 (1.35–5.82)
 >74177176.01 (2.70–13.39)4.33 (1.90–9.89)
Updated Charlson score#
 01947751.000.082 (ptrend)1.000.037 (ptrend)
 1717230.83 (0.51–1.33)1.02 (0.61–1.69)
 211681.85 (0.87–3.93)1.63 (0.75–3.54)
 ≥340+3.57 (1.36–9.36)3.88 (1.43–10.58)
IMD score27601090.99 (0.98–1.01)0.3811.00 (0.98–1.01)0.521
Type of operation
 VATS703141.000.0021.000.004
 Open362213.03 (1.52–6.03)2.94 (1.41–6.11)
 Unclear or not specified§1755762.23 (1.25–3.97)2.37 (1.29–4.36)
Provisional diagnosisƒ
 J84.11433761.00<0.0011.000.008
 J84.9812280.64 (0.41–0.99)0.76 (0.48–1.20)
 J84.899+0.18 (0.03–1.32)0.23 (0.03–1.65)
 RA-ILD160
 CTD-ILD38+0.99 (0.23–4.20)0.91 (0.21–3.94)
 HP162+0.34 (0.11–1.08)0.45 (0.13–1.55)
 Sarcoidosis260+0.07 (0.01–0.50)0.10 (0.01–0.74)
  • Data are presented as n, unless otherwise stated. OR: odds ratio; IMD: Index of Multiple Deprivation 2010; VATS: video-assisted thoracoscopic surgery. #: higher updated Charlson score reflects greater degree of comorbidity; : lower IMD score reflects least deprived; +: 1–5 (small numbers hidden to aid confidentiality); §: mainly reflects older data from before a specific code for VATS was available (these cases are likely to be a combination of open and VATS procedures, with increasing numbers of VATS in later years); ƒ: J84.1: other interstitial pulmonary disease with fibrosis; J84.9: interstitial pulmonary disease, unspecified; J84.8: other specified interstitial pulmonary disease; RA-ILD (J99.0): rheumatoid lung disease; CTD-ILD (J99.1): respiratory disorders in other diffuse connective tissue disorders; HP (J67.9): hypersensitivity pneumonitis due to unspecified organic dust; sarcoidosis (D86.0): sarcoidosis of lung.