TABLE 1

Systemic organ and vasculitic manifestations in 157 patients with eosinophilic granulomatosis with polyangiitis throughout the course of the disease

Asthma157 (100%)
Eosinophilia#157 (100%)
General manifestations
 Fever >38°C62 (39%)
 Weight loss (>5% or 3 kg in the past 3 months)73 (46%)
 Myalgia60 (38%)
 Polyarthralgias39 (25%)
Cardiac and vascular manifestations
 Myocarditis49 (31%)
  Patent36 (23%)
  Latent+12 (8%)
 Myocardial infarction1 (1%)
 Arrhythmia or atrioventricular block12 (8%)
 Pericarditis (echocardiography and/or CT)32 (20%)
 Small effusion23 (15%)
 Large effusion4 (3%)
 Large effusion requiring drainage5 (3%)
 Venous thromboembolism8 (5%)
Renal manifestations
 Crescentic glomerulonephritis (biopsy proven)9 (6%)
 Other glomerulonephritis (focal segmental glomerulonephritis, membranous glomerulonephritis)2 (1%)
 Interstitial nephritis0
 Proteinuria >0.3 g·day−119 (12%)
 Renal failure (creatinine >124 µmol·L−1 or 1.4 mg·dL−1)7 (4%)
Neurological manifestations
 Mononeuritis multiplex56 (36%)
 Peripheral neuropathy43 (27%)
Cutaneous manifestations
 Vascular purpura (palpable)26 (17%)
 Subcutaneous nodules7 (4%)
 Livedo2 (1%)
 Urticaria13 (8%)
Gastro-intestinal manifestations
 Abdominal pain (associated with nausea, vomiting, diarrhoea)33 (21%)
 Digestive haemorrhage4 (3%)
Other
 Eye involvement2 (1%)
 Urogenital1 (1%)
  • CT: computed tomography. #: defined as peripheral blood eosinophilia >1.5×109 L−1 or 10% of leukocytes; : i.e. clinical manifestations of heart failure and/or decreased systolic ejection fraction, increased N-terminal pro-brain natriuretic petide, increased troponin I; +: isolated magnetic resonance imaging abnormalities.