Associations between baseline high attenuation areas (HAA) and interstitial lung abnormalities (ILA) at 9.5 years of follow-up in Multi-Ethnic Study of Atherosclerosis (MESA) participants#

HAAp-value for trendOverallp-value
Quartile 1Quartile 2Quartile 3Quartile 4
Number with ILA617272101306
ILA prevalence %<0.00110.5
OR (95% CI)OR (95% CI) per doubling of HAA
UnadjustedRef1.14 (0.80–0.84)1.20 (0.84–1.72)1.76 (1.25–2.46)<0.0011.47 (1.21–1.79)<0.001
AdjustedRef1.42 (0.93–2.17)1.79 (1.11–2.89)3.07 (1.77–5.33)<0.0011.95 (1.43–2.65)<0.001
Adjusted, stratified by smoking status+
 Ever-smokersRef1.14 (0.66–1.99)1.53 (0.84–2.81)2.31 (1.13–4.73)0.0092.38 (1.57–3.60)<0.001
 Never-smokersRef2.34 (1.18–4.64)2.55 (1.15–5.65)5.55 (2.24–13.77)<0.0011.59 (0.99–2.55)0.053
  • #: ILA assessment was completed on 2907 MESA participants who also had complete HAA data, over 9.5 years of follow-up. 477 of these participants had scans read as equivocal for ILA and were excluded from analyses. : adjusted for age, sex, race/ethnicity, educational attainment, height, body mass index, waist circumference, smoking status, cigarette pack-years, glomerular filtration rate, study site, mA dose, total volume of imaged lung and percentage emphysema. Adjustment for smoking status and pack-years was excluded from smoking-stratified models. All covariates measured at baseline examination in 2000–2002. +: p-value for interaction 0.24.