Criteria for diagnosis of asthma–chronic obstructive pulmonary disease overlap syndrome

1. Persistent airflow limitation (post-bronchodilator FEV1/FVC <0.70 or LLN) in individuals 40 years of age or older; LLN is preferred1. Documented history of atopy or allergic rhinitis
2. At least 10 pack-years of tobacco smoking
equivalent indoor or outdoor air pollution exposure (e.g. biomass)
2. BDR of FEV1 ≥200 mL and 12% from baseline values on 2 or more visits
3. Documented history of asthma before 40 years of age
BDR of >400 mL in FEV1
3. Peripheral blood eosinophil count of ≥300 cells·uL−1
  • The committee recommends presence of all three major criteria and at least one minor criterion for asthma-chronic obstrucive pulmonary disease overlap syndrome. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; BDR: bronchodilator response using 400 ug of albuterol/salbutamol (or equivalent); LLN: lower limit of normal.