HAA | p-value for trend | Overall | p-value | ||||
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||||
Number at-risk | 1699 | 1699 | 1700 | 1699 | 6808 | ||
Number of decedents | 252 | 237 | 283 | 321 | 1093 | ||
Person-years of observation | 19 010 | 18 805 | 18 844 | 18 347 | 75 006 | ||
Mortality rate per 1000 person-years | 13.3 | 12.6 | 15.0 | 17.5 | 14.6 | ||
HR (95% CI) | HR (95% CI) per doubling of HAA | ||||||
Model 1# | Ref | 1.15 (0.94–1.40) | 1.51 (1.23–1.87) | 1.94 (1.53–2.46) | <0.001 | 1.58 (1.39–1.79) | <0.001 |
Model 2¶ | Ref | 1.15 (0.95–1.41) | 1.52 (1.23–1.88) | 1.91 (1.51–2.43) | <0.001 | 1.55 (1.37–1.77) | <0.001 |
Model 2, stratified by smoking status+ | |||||||
Ever-smokers | Ref | 1.35 (1.05–1.72) | 1.65 (1.27–2.15) | 2.42 (1.81–3.22) | <0.001 | 1.78 (1.50–2.11) | <0.001 |
Never-smokers | Ref | 1.02 (0.73–1.43) | 1.40 (0.99–2.00) | 1.55 (1.02–2.35) | 0.02 | 1.38 (1.12–1.70) | 0.002 |
#: adjusted for age, sex, race/ethnicity, educational attainment, height, body mass index, waist circumference, smoking status, cigarette pack-years, glomerular filtration rate, study site, mA dose, total volume of imaged lung and percent emphysema. Adjustment for smoking status and pack-years was excluded from smoking-stratified models. All covariates measured at baseline examination in 2000–2002. ¶: model 2 is additionally adjusted for alcohol use, exercise, coronary artery calcium, diabetes medication use, insulin use, fasting glucose level, hypertension, antihypertensive medication use, systolic and diastolic blood pressures, cholesterol medication use, total and high-density lipoprotein cholesterol levels, C-reactive protein level, D-dimer level and history of cancer. +: p-value for interaction 0.56.