TABLE 3

Mean change in forced expiratory volume in 1 s (FEV1) % predicted per year in different patient subgroups, estimated from multilevel models

Patient subgroupsMean change in FEV1 % pred per yearRange for 95% of patients' changes in FEV1 % predPatients in model#
Ciliary ultrastructure by TEM
 Microtubular defects−0.75−2.08–0.5818
 Outer±inner arm defect−0.51−1.41–0.3964
 Normal or inconclusive−0.13−1.53–1.2815
Extent of bronchiectasis+
 <44%−0.08−0.92–0.7520
 ≥44% and <55%−0.65−1.52–0.2225
 ≥55%−0.59−2.13–0.9523
Severity of bronchial wall dilatation+
 <33%0.16−0.20–0.5312
 ≥33% and <67%−0.57−1.31–0.1742
 ≥67%−0.89−2.74–0.9514
  • TEM: transmission electron microscopy. #: models were run for different patient subgroups depending on their ciliary ultrastructure, extent of bronchiectasis and severity of bronchial wall dilatation; as well as this, patients were required to have non-missing data for FEV1, age at the time the FEV1 measure was taken and any other variables in the model. : model stratified by ciliary ultrastructure by TEM categories. +: models stratified by high-resolution computed tomography categories where there was evidence of interaction with age (p<0.05); all adjusted for ciliary ultrastructure by TEM.