Diagnostic performance of various criteria for discriminating controls versus patients with PVD and LHD
| Patients n | mPAPmax+TPRmax# | mPAP–COslope¶ | ΔmPAP/ΔCO+ | ||||
| Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | ||
| All | 169 | 0.93 (0.86–0.96) | 1.0 (0.95–1.0) | 0.72 (0.62–0.81) | 0.88 (0.78–0.95) | 0.94 (0.88–0.98) | 0.87 (0.76–0.94) |
| Diagnosis | |||||||
| PVD | 49 | 0.94 (0.84–0.98) | 1.0 (0.95–1.0) | 0.67 (0.52–0.80) | 0.88 (0.78–0.95) | 0.88 (0.75–0.95) | 0.87 (0.76–0.94) |
| LHD | 52 | 0.92 (0.82–0.97) | 1.0 (0.95–1.0) | 0.77 (0.63–0.87) | 0.88 (0.78–0.95) | 1.0 (0.93–1.0) | 0.87 (0.76–0.94) |
#: sensitivity and specificity values based on peak mean pulmonary arterial pressure (mPAPmax) >30 mmHg and peak total pulmonary resistance (TPRmax) >3 WU; ¶: sensitivity and specificity values based on the mPAP–cardiac output slope (mPAP–COslope) >3 WU; +: sensitivity and specificity values based on the ratio of mPAPmax minus resting mPAP over peak cardiac output minus resting cardiac output (ΔmPAP/ΔCO) >3 WU. PVD: pulmonary vascular disease; LHD: left heart disease.