Scenario | Incremental absolute percentage of receiving lung transplantation | Additional life expectancy years | Additional quality-adjusted life-years | Incremental lifetime costs US$ |
Optimistic | −29.53 (−26.44–−33.38) | 30.59 (27.31–33.68) | 25.64 (21.79–29.12) | 3 540 660 (1 310 481–5 507 336) |
Intermediate | −19.01 (−14.98–−23.01) | 19.23 (15.15–22.54) | 15.85 (12.37–18.93) | 3 388 927 (1 451 385–4 817 945) |
Conservative | −1.16 (−0.79–−1.59) | 1.16 (0.91–1.49) | 0.91 (0.71–1.18) | 443 814 (−511 469–727 012) |
6-year-old | −18.50 (−22.05–−14.82) | 18.09 (14.63–21.13) | 14.92 (11.92–17.95) | 3 740 480 (2 199 261–4 915 629) |
9-year-old | −19.74 (−15.91–−23.59) | 19.30 (15.39–22.60) | 15.83 (12.27–19.19) | 3 517 034 (1 936 263–4 716 440) |
12-year-old | −20.04 (−15.72–−23.91) | 19.56 (14.87–23.56) | 16.03 (12.03–19.57) | 3 455 593 (1 715 960–4 680 515) |
Data are presented as n (95% credible interval), ivacaftor plus usual care versus usual care alone.