Blood-culture-positive pneumococcal pneumonia | Blood-culture-negative pneumococcal pneumonia | p-value | |
Subjects | 362 | 555 | |
Clinical data on admission | |||
Days of symptoms | 4 (2–6) | 4 (2–7) | 0.74 |
Cough | 301 (85) | 456 (83) | 0.53 |
Expectoration | 221 (64) | 389 (72) | 0.008 |
Dyspnoea | 248 (70) | 397 (73) | 0.41 |
Pleuritic pain | 208 (59) | 274 (50) | 0.007 |
Fever | 313 (88) | 449 (81) | 0.011 |
Confusion | 83 (23) | 101 (18) | 0.074 |
Respiratory rate breaths·min−1 | 28 (24–32) | 28 (20–32) | 0.014 |
Heart rate beats·min−1 | 104 (92–120) | 100 (87–110) | <0.001 |
Temperature °C | 38.0 (37.5–38.7) | 37.7 (36.9–38.5) | <0.001 |
Laboratory data on hospital admission | |||
Creatinine mg·dL−1 | 1.2 (0.9–1.6) | 1.1 (0.9–1.4) | 0.001 |
Creatinine ≥1.5 mg·dL−1 | 113 (31) | 132 (24) | 0.014 |
C-reactive protein mg·dL−1 | 26.4 (17.3–34) | 19.8 (9.3–28.7) | <0.001 |
C-reactive protein ≥20 mg·dL−1# | 183 (71) | 197 (50) | <0.001 |
WBC count 109 L−1 | 15.3 (9.8–20.5) | 14.4 (9.9–19.4) | 0.25 |
WBC count ≥10×109 L−1 | 266 (74) | 410 (75) | 0.84 |
SaO2 % | 92.5 (88.1–95.0) | 93.2 (90.3–95.7) | 0.014 |
SaO2 <92% | 101 (43) | 111 (35) | 0.044 |
PaO2/FIO2 mmHg | 271.4 (228.6–302.9) | 281.0 (238.1–328.6) | 0.002 |
PaO2/FIO2 <250 mmHg | 109 (41) | 133 (32) | 0.015 |
Data are presented as n, median (interquartile range) or n (%), unless otherwise stated. Percentages calculated on nonmissing data. WBC: white blood cell; SaO2: arterial oxygen saturation; PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction. #: optimal cut-off value to predict bacteraemic pneumococcal pneumonia using receiver operating characteristic curves.