TABLE 2

Clinical characteristics and haemodynamic findings

mPAP ≤20 mmHgmPAP 21–24 mmHgp-value
Subjects n20486
Age years55±1552±150.16
Female:male ratio2.2:1.01.9:1.00.59
BMI kg·m−224.7±5.225.5±4.80.24
Risk factor for PVD %61.867.40.42
Risk factor for LHD %43.145.30.80
6MWD m471±109423±1100.002
NYHA functional class I/II/III %19/54/2710/48/420.03
Peak workload W54.4±27.044.0±21.70.002
RestPeakRestPeak
Heart rate beats·min−173±12114±2072±12114±16
mPAP mmHg16.4±2.934.5±8.422.7±1.2***43.7±7.9***
PAWP mmHg7.3±3.317.2±8.48.4±3.2**18.3±8.7
TPG mmHg9.2±3.517.2±7.414.3±3.5***25.5±8.2***
CO L·min−16.0±1.511.8±3.15.9±1.410.8±3.2**
PVR WU1.6±0.81.6±0.82.6±0.8***2.5±1.0***
TPVR WU2.9±0.93.2±1.24.0±0.9***4.3±1.3***
Power W0.27±0.091.12±0.400.37±0.09***1.33±0.53**
  • Data are presented as mean±sd, unless otherwise indicated. mPAP: mean pulmonary artery pressure; BMI: body mass index; PVD: pulmonary vascular disease; LHD: left heart disease; 6MWD: 6-min walk distance; NYHA: New York Heart Association; PAWP: pulmonary artery wedge pressure; TPG: transpulmonary gradient; CO: cardiac output; PVR: pulmonary vascular resistance; TPVR: total pulmonary vascular resistance. **: p<0.01; ***: p<0.001 versus respective rest or peak values in mPAP normal group.